Need an ultrasound? We got an app for that!
Phone attachment and AI does the trick
Jonathan Rothberg, a entrepreneur who prides himself on drastically disrupting the biomedical industry every so often, has typically big claims for his new product. The Butterfly iQ, a cheap handheld ultrasound tool with AI smarts tucked inside, will 1) revolutionize medical imaging in hospitals and clinics, 2) change the game in global health, and 3) eventually become a consumer product that will be as ubiquitous as the household thermometer, he says.
Today, Rothbergâ€™s startup Butterfly Network unveiled the tool and announced its FDA clearance for 13 clinical applications, including cardiac scans, fetal and obstetric exams, and musculoskeletal checks. Rather than using a dedicated piece of hardware for the controls and image display, the iQ works with the userâ€™s iPhone. The company says it will start shipping units in 2018 at an initial price of about $2,000.
But thatâ€™s just the beginning, Rothberg tells IEEE Spectrum. He expects to bring the price down on the handheld gadget, and is already looking ahead to radically new products. â€œIn the next two years weâ€™ll release a patch that uses ultrasound to monitor patients, and a pill you can swallow to look at cancer from within the body,â€ he says.
All these form factors are possible because Butterfly uses a very different technology than conventional ultrasound. Its â€œultrasound on a chipâ€ takes advantage of the mass-market fabrication techniques perfected for computer chips, Rothberg says. â€œWe put all the elements onto a semiconductor wafer, then we can dice up the wafer to make 48 ultra low-cost ultrasound machines,â€ he says.
Todayâ€™s ultrasound systems use piezoelectric crystals, which convert electrical energy into vibrations in the form of ultrasonic waves. A typical system has a display screen on a bulky cart with several wands for imaging at different depths within the body. These machines can cost upwards of $100,000. While a few smaller and cheaper devices exist, such as GEâ€™s handheld Vscan products, they still use pricey piezoelectric technology and require multiple probes, bringing the price to something between $8,000 and $20,000.
Developing the iQâ€™s chip-based technology was a two-step process. First, Butterflyâ€™s engineers replaced the piezoelectrics with a micromachine that acts like a tiny drum to generate vibrations. Inside this â€œcapacitive micromachined ultrasound transducerâ€ (CMUT), an applied voltage moves a membrane to send ultrasonic waves into the body. The waves that bounce back from various body tissues move the membrane and are registered as an electric signal, which creates the image. Butterfly based its technology on research done by Stanford professor Pierre Khuri-Yakub, who serves on Butterflyâ€™s scientific advisory board.
Rothberg explains that typical ultrasound systems require separate probes for different clinical applications because the crystals have to be tuned at the time of manufacture to produce the right type of ultrasonic wave for imaging at a particular depth. But the Butterfly iQ can be tuned on the fly. â€œWe have 10,000 of these micromachine transducers on a probe, and that gives us a monster dynamic range,â€ he says. “We can make them buzz at 1 megahertz if we want to go deep, or 5 megahertz if we want to go shallow.â€
The second innovation was to do away with the wiring that connects a typical piezoelectric probe to the electronic controls and displays. Butterflyâ€™s micromachines are attached directly to a semiconductor layer that contains all the necessary amplifiers, signal processors, and so on.
Independent experts say the technology sounds promising, but theyâ€™ll wait to see if the Butterfly iQ can live up to Rothbergâ€™s claims. â€œPeople in medicine tend to be conservative, and Iâ€™m skeptical when someone claims to have found a wonderdrug or cure,â€ says Torben Becker, an emergency room physician at the University of Florida hospital who has researched the use of portable ultrasound tools by paramedics and in the developing world.